According to research released in the Journal of Biological Chemistry, Brown University and Lifespan “researchers show that in the brain cells of rats, obesity impedes the production of a hormone that curbs appetite and inspires calorie burning. The root cause appears to be a breakdown in the protein-processing mechanism of the cells.”
If the research proves to be true for humans, it would mean that the obese would suffer from a vicious cycle, prompted by the change in their brain chemistry, that undermined their ability to suppress appetite and to increase calorie burning. In other words, the very condition of being overweight keeps one overweight, which might add credence to the statements that many obese people make that they can’t lose weight.
Researchers said that the change in brain chemistry could be battled with drugs, but they are not readily applicable as medicines for treating obesity in humans.